Representing default knowledge in biomedical ontologies: application to the integration of anatomy and phenotype ontologies
نویسندگان
چکیده
منابع مشابه
بررسی هستان شناسی های توسعه یافته مبتنی بر اصول هستان شناسی های منبع باز زیست پزشکی
Background and Aim: Ontologies facilitate data integration, exchange, searching and querying. Open Biomedical Ontologies (OBO) Foundry is a solution for creating reference ontologies. In this foundry, the design of ontologies is based on established principles which allow for their interactions as a single system. The purpose of this study is to determine the main features of ontologies develop...
متن کاملInteroperability between phenotype and anatomy ontologies
MOTIVATION Phenotypic information is important for the analysis of the molecular mechanisms underlying disease. A formal ontological representation of phenotypic information can help to identify, interpret and infer phenotypic traits based on experimental findings. The methods that are currently used to represent data and information about phenotypes fail to make the semantics of the phenotypic...
متن کاملThe anatomy of phenotype ontologies: principles, properties and applications.
The past decade has seen an explosion in the collection of genotype data in domains as diverse as medicine, ecology, livestock and plant breeding. Along with this comes the challenge of dealing with the related phenotype data, which is not only large but also highly multidimensional. Computational analysis of phenotypes has therefore become critical for our ability to understand the biological ...
متن کاملThe zebrafish anatomy and stage ontologies: representing the anatomy and development of Danio rerio
BACKGROUND The Zebrafish Anatomy Ontology (ZFA) is an OBO Foundry ontology that is used in conjunction with the Zebrafish Stage Ontology (ZFS) to describe the gross and cellular anatomy and development of the zebrafish, Danio rerio, from single cell zygote to adult. The zebrafish model organism database (ZFIN) uses the ZFA and ZFS to annotate phenotype and gene expression data from the primary ...
متن کاملRepresenting and Using Ontologies
This paper discusses the representation of large ontologies, especially in a graphical format. It describes a tool, developed using Java, that incorporates several abstraction mechanisms that can help manage such ontologies. Furthermore, it briefly analyzes possible point-and-click approaches that can be used to form queries on these ontologies. 1 This research was partially done under a cooper...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2007
ISSN: 1471-2105
DOI: 10.1186/1471-2105-8-377